A genetic TRP down the channel to praziquantel resistance

Abstract

TThe anthelmintic praziquantel (PZQ) is an essential tool in controlling schistosomiasis, so reports of reduced PZQ efficacy are of great public health concern. Le Clec’h et al. recently identified a gene responsible for PZQ resistance in experimentally selected resistant Schistosoma mansoni. The importance of this locus in natural infections remains to be established.

James Cotton

Professor

My research interests are in the genomics, and particularly population genomics of parasites, particularly those that cause neglected tropical diseases