building reference genome and transcriptome resources
Last updated on
Apr 19, 2021
My first involvement in parasitology was through leading reference genome sequencing, assembly and annotation projects for a number of key helminth species of medical and veterinary importance. This inlucdes the nematodes Haemonchus contortus, Globodera pallida and Onchocerca volvulus. I also contributed data or analysis to other projects (Trichuris muris, Strongyloides spp., Tsetse fly, Globodera rostochiensis and an updated Brugia malayi). I played a fairly big part in a large-scale effort to produce reference genomes for most key helminth species, which became the helminth genomes consortium.
James Cotton
Professor
My research interests are in the genomics, and particularly population genomics of parasites, particularly those that cause neglected tropical diseases
Publications
Lymphatic filariasis affects ∼120 million people and can result in elephantiasis and hydrocele. Here, we report the nearly complete …
A. Tracey, J. M. Foster, M. Paulini, A. Grote, J. Mattick, Y. C. Tsai, M. Chung, James Cotton, T. A. Clark, A. Geber, N. Holroyd, J. Korlach, S. Libro, S. Lustigman, M. L. Michalski, M. B. Rogers, A. Twaddle, J. C. Dunning Hotopp, M. Berriman, E. Ghedin
Avian malaria parasites are prevalent around the world and infect a wide diversity of bird species. Here, we report the sequencing and …
U. Böhme, T. D. Otto, James Cotton, S. Steinbiss, M. Sanders, S. O. Oyola, A. Nicot, S. Gandon, K. P. Patra, C. Herd, E. Bushell, K. K. Modrzynska, O. Billker, J. M. Vinetz, A. Rivero, C. I. Newbold, M. Berriman
The unicellular protozoan parasite Leishmania causes the neglected tropical disease leishmaniasis, affecting 12 million people in 98 …
S. Coughlan, A. S. Taylor, E. Feane, M. Sanders, G. Schönian, James Cotton, T. Downing
Control of pathogens arising from humans, livestock and wild animals can be enhanced by genome-based investigation. Phylogenetically …
S. Coughlan, P. Mulhair, M. Sanders, G. Schönian, James Cotton, T. Downing
Elucidation of the evolutionary history and interrelatedness of Plasmodium species that infect humans has been hampered by a lack of …
G. G. Rutledge, U. Böhme, M. Sanders, A. J. Reid, James Cotton, O. Maiga-Ascofare, A. A. Djimdé, T. O. Apinjoh, L. Amenga-Etego, M. Manske, J. W. Barnwell, F. Renaud, B. Ollomo, F. Prugnolle, N. M. Anstey, S. Auburn, R. N. Price, J. S. McCarthy, D. P. Kwiatkowski, C. I. Newbold, M. Berriman, T. D. Otto
Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to …
James Cotton, S. Bennuru, A. Grote, B. Harsha, A. Tracey, R. Beech, S. R. Doyle, M. Dunn, J. C. Hotopp, N. Holroyd, T. Kikuchi, O. Lambert, A. Mhashilkar, P. Mutowo, N. Nursimulu, J. M. Ribeiro, M. B. Rogers, E. Stanley, L. S. Swapna, I. J. Tsai, T. R. Unnasch, D. Voronin, J. Parkinson, T. B. Nutman, E. Ghedin, M. Berriman, S. Lustigman
The yellow potato cyst nematode, Globodera rostochiensis, is a devastating plant pathogen of global economic importance. This …
S. Eves-van den Akker, D. R. Laetsch, P. Thorpe, C. J. Lilley, E. G. Danchin, M. Da Rocha, C. Rancurel, N. E. Holroyd, James Cotton, A. Szitenberg, E. Grenier, J. Montarry, B. Mimee, M. O. Duceppe, I. Boyes, J. M. Marvin, L. M. Jones, H. B. Yusup, J. Lafond-Lapalme, M. Esquibet, M. Sabeh, M. Rott, H. Overmars, A. Finkers-Tomczak, G. Smant, G. Koutsovoulos, V. Blok, S. Mantelin, P. J. Cock, W. Phillips, B. Henrissat, P. E. Urwin, M. Blaxter, J. T. Jones
Whipworms are common soil-transmitted helminths that cause debilitating chronic infections in man. These nematodes are only distantly …
B. J. Foth, I. J. Tsai, A. J. Reid, A. J. Bancroft, S. Nichol, A. Tracey, N. Holroyd, James Cotton, E. J. Stanley, M. Zarowiecki, J. Z. Liu, T. Huckvale, P. J. Cooper, R. K. Grencis, M. Berriman
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed …
International Glossina Genome Initiative
Globodera pallida is a devastating pathogen of potato crops, making it one of the most economically important plant parasitic …
James Cotton, C. J. Lilley, L. M. Jones, T. Kikuchi, A. J. Reid, P. Thorpe, I. J. Tsai, H. Beasley, V. Blok, P. J. Cock, S. Eves-van den Akker, N. Holroyd, M. Hunt, S. Mantelin, H. Naghra, A. Pain, J. E. Palomares-Rius, M. Zarowiecki, M. Berriman, J. T. Jones, P. E. Urwin
The small ruminant parasite Haemonchus contortus is the most widely used parasitic nematode in drug discovery, vaccine development and …
R. Laing, T. Kikuchi, A. Martinelli, I. J. Tsai, R. N. Beech, E. Redman, N. Holroyd, D. J. Bartley, H. Beasley, C. Britton, D. Curran, E. Devaney, A. Gilabert, M. Hunt, F. Jackson, S. L. Johnston, I. Kryukov, K. Li, A. A. Morrison, A. J. Reid, N. Sargison, G. I. Saunders, J. D. Wasmuth, A. Wolstenholme, M. Berriman, J. S. Gilleard, James Cotton
Toxoplasma gondii is a zoonotic protozoan parasite which infects nearly one third of the human population and is found in an …
A. J. Reid, S. J. Vermont, James Cotton, D. Harris, G. A. Hill-Cawthorne, S. Könen-Waisman, S. M. Latham, T. Mourier, R. Norton, M. A. Quail, M. Sanders, D. Shanmugam, A. Sohal, J. D. Wasmuth, B. Brunk, M. E. Grigg, J. C. Howard, J. Parkinson, D. S. Roos, A. J. Trees, M. Berriman, A. Pain, J. M. Wastling
Bursaphelenchus xylophilus is the nematode responsible for a devastating epidemic of pine wilt disease in Asia and Europe, and …
T. Kikuchi, James Cotton, J. J. Dalzell, K. Hasegawa, N. Kanzaki, P. McVeigh, T. Takanashi, I. J. Tsai, S. A. Assefa, P. J. Cock, T. D. Otto, M. Hunt, A. J. Reid, A. Sanchez-Flores, K. Tsuchihara, T. Yokoi, M. C. Larsson, J. Miwa, A. G. Maule, N. Sahashi, J. T. Jones, M. Berriman