Leishmaniasis in Ethiopia

Last updated on Apr 19, 2021

Working with some excellent Ethiopian collaborators and in particular Pascale Kropf at Imperial college, London, we are using parasite genetics and RNA-seq of clinical samples to understand the pathogenesis and epidemiology of leishmaniasis in Ethiopia. Ethiopia is a uniquely interesting place for Leishmania research where a unique form of cutaneous leishmanaisis (CL), caused by L. aethiopica co-exists close to foci of VL due to two different genotypes of L. dononvani, which are separated by the East African rift valley. We have three on-going projects funded my the MRC and by a Wellcome fellowship awarded to Yegnasew Takele to work with Pascale.

James Cotton
James Cotton
Professor

My research interests are in the genomics, and particularly population genomics of parasites, particularly those that cause neglected tropical diseases

Publications

Demographic characteristics and clinical features of patients presenting with different forms of cutaneous leishmaniasis, in Lay Gayint, Northern Ethiopia
Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by Leishmania parasites, that can cause long-term chronic …
E. Yizengaw, B. Gashaw, M. Yimer, Y. Takele, E. Nibret, G. Yismaw, E. Cruz Cervera, K. Ejigu, D. Tamiru, A. Munshea, I. Müller, R. Weller, James Cotton, L. A. C. Chapman, P. Kropf
PDF Project DOI medRxiv
Demographic characteristics and prevalence of asymptomatic Leishmania donovani infection in migrant workers working in an endemic area in Northwest Ethiopia
Visceral leishmaniasis (VL), a neglected tropical disease that causes substantial morbidity and mortality, is a serious health problem …
M. Yimer, Y. Takele, E. Yizengaw, E. Nibret, P. Sumova, P. Volf, G. Yismaw, M. Alehegn, A. Rowan, I. Müller, James Cotton, L. A. C. Chapman, P. Kropf
PDF Project DOI medRxiv
Cutaneous leishmaniasis in a newly established treatment centre in the Lay Gayint district, Northwest Ethiopia
Background Cutaneous leishmaniasis (CL) is a neglected tropical disease that primarily affects the most vulnerable populations. In …
E. Yizengaw, E. Nibret, G. Yismaw, B. Gashaw, D. Tamiru, A. Munshea, Y. Takele, I. Müller, L. Chapman, R. Weller, James Cotton, P. Kropf
PDF Project DOI publisher
Recurrent visceral leishmaniasis relapses in HIV co-infected patients are characterized by less efficient immune responses and higher parasite load
Visceral leishmaniasis (VL) and HIV co-infection (VL/HIV) has emerged as a significant public health problem in Ethiopia, with up to …
Y. Takele, T. Mulaw, E. Adem, R. Womersley, M. Kaforou, S. U. Franssen, M. Levin, G. P. Taylor, I. Müller, James Cotton, P. Kropf
PDF Project DOI publisher Yegnasew Takele
Impaired in vitro Interferon-gamma production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation
Visceral leishmaniasis (VL) is a neglected tropical disease that causes substantial morbidity and mortality and is a growing health …
Y. Takele, E. Adem, S. U. Franssen, R. Womersley, M. Kaforou, M. Levin, I. Müller, James Cotton, P. Kropf
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HIV-1 co-infection increases relapse rate and shortens survival in patients with visceral leishmaniasis
Patients co-infected with visceral leishmaniasis (VL) and HIV-1 (VL/HIV patients) suffer from recurrent VL relapses and increased …
Y. Takele, T. Mulaw, E. Adem, R. Womersley, M. Kaforou, S. U. Franssen, M. Levin, G. P. Taylor, I. Müller, James Cotton, P. Kropf
PDF Project DOI medRxiv Yegnasew Takele
Diversity and Within-Host Evolution of Leishmania donovani from Visceral Leishmaniasis Patients with and without HIV Coinfection in Northern Ethiopia
Visceral leishmaniasis (VL) is a fatal disease and a growing public health problem in East Africa, where Ethiopia has one of the …
S. U. Franssen, Y. Takele, E. Adem, M. J. Sanders, I. Müller, P. Kropf, James Cotton
PDF Cite Project DOI publisher medRxiv Yegnasew Takele Suse Franssen
Immunological factors, but not clinical features, predict visceral leishmaniasis relapse in patients co-infected with HIV
Visceral leishmaniasis (VL) has emerged as a clinically important opportunistic infection in HIV patients, as VL/HIV co-infected …
Y. Takele, T. Mulaw, E. Adem, C. J. Shaw, S. U. Franssen, R. Womersley, M. Kaforou, G. P. Taylor, M. Levin, I. Müller, James Cotton, P. Kropf
PDF Project DOI bioRxiv publisher Yegnasew Takele